Although he never met with the producers or the director Mike Bay, Bay felt his Welker's G1 Megatron voice did not fit the film and Bay's new interpretation. Ironically, he recreated the G1 voice for the "Transformer Game" based on the movie, and was once again reunited with his old nemesis Optimus Prime played by Peter Cullen.
Became the sixth actor to appear in 2 films to gross $1 billion with Alice in Wonderland (2010), and Transformers: Dark Side of the Moon(2011). He is the first voice actor to achieve this feat.
Has done voices for both the original Star Trek film series and the television series "Star Trek: Voyager" (1995).
Has shared two roles with Leonard Nimoy. When the third season of "The Transformers" (1984) came around, Frank took the role of Galvatron that Leonard Nimoy had taken in The Transformers: The Movie (1986). And in Star Trek III: The Search for Spock (1984), Frank provided the screams of Leonard Nimoy's most famous character, Spock.
He also did the animal voice effects including Dumbo in Who Framed Roger Rabbit (1988).
He has done every voicing of Freddy "Fred" Jones for all of the Scooby-Doo series with the sole exception of "A Pup Named Scooby-Doo" (1988). Even in parodies and cameos on different TV shows, he has always done this voice.
He has played the same character (Freddy Jones) on 14 different series: "Scooby Doo, Where Are You!" (1969), "The New Scooby-Doo Movies" (1972), "The Scooby-Doo/Dynomutt Hour" (1976), "Dynomutt Dog Wonder" (1978), "Scooby-Doo and Scrappy-Doo" (1979), "The Scooby and Scrappy-Doo Puppy Hour" (1982), "The New Scooby-Doo Mysteries" (1984), "Scooby's Mystery Funhouse" (1985), "Family Guy" (1999), "Harvey Birdman
His "Dr. Claw" voice came about as a result of him trying to do an impression of Barry White.
His "Dr. Claw" voice is arguably his most famous role. Aside from playing Dr. Claw in "Inspector Gadget" (1983), he has used the voice for other characters, such as Darkseid in "SuperFriends: The Legendary Super Powers Show" (1984), Emperor Krulos in "Dino-Riders" (1988), Soundwave in "The Transformers" (1984) (only heavily modified with a vocoder, to give it a distinct monotone, robotic sound), as well as in movies such as the Cave of Wonders in Aladdin (1992), Shao Kahn in Mortal Kombat (1995), Soundwave again in both Transformers: Revenge of the Fallen (2009) and Transformers: Dark of the Moon (2011) (without the vocoder effects), as well as playing the Devil in four different movies; The Golden Child (19
His broad spectrum of character voices, noises, and other vocal effects that have appeared over the last 40 years in motion pictures, have vaulted him to number one on the "All Time Top 100 Stars at the Box office" list. The revenue of films he has participated in have generated over 12 billion dollars worldwide. His work in over 90 films has put him ahead of Eddie Murphy, Harrison Ford, Tom Hanks and Samuel L. Jackson.
In "Tiny Toon Adventures" (1990), he voiced Furrball, Gogo Dodo, Calamity Coyote, Little Beeper, Byron Basset, Uncle Stinky Pig, Henry Bear, and Ralph the Guard who later appeared in "Animaniacs" (1993), where Frank not only voiced Ralph, but also voiced Thaddeus Plotz, Buttons, Runt, Flavio Hippo, and Chicken Boo.
One of the most prolific voice actors of all time, he has been involved with some of the most popular and important animated programs of all time as well, beginning with his role as level headed leader Fred Jones in Scooby-Doo, the evil Decepticon leader Megatron in The Transformers (among others), Dr. Ray Stantz in The Real Ghostbusters, and a variety of supporting roles in G.I. Joe, Tiny Toons, Animaniacs, and The Smurfs.
Provided the voice for 8 of the original 14 Decepticons in the "The Transformers" (1984) cartoon: Megatron, Soundwave, Skywarp, Lazerbeak, Rumble, Frenzy, Ravage, and Buzzsaw. He voiced two of the original Autobots as well: Trailbreaker and Mirage, as well as one of the Dinobots (Sludge) that also appeared in the first season.
Referred to in Hollywood as a voice god.