He was the original voice in Warner Bros. cartoons of "Elmer Fudd", whose nemesis was "Bugs Bunny" and some times "Daffy Duck".
Played the title role in "The Major Hoople" radio series that debuted on NBC's Blue Network on June 22, 1942. Based on Gene Ahern's comic strip "Our Boarding House", Bryan co-starred with Patsy Moran as The Major's wife Martha Hoople. Mel Blanc, who would later portray Bugs Bunny to Bryan's Elmer Fudd, played the star boarder, Tiffany Twiggs on the 30-minute program, which aired on Mondays at 7 pm. The series went off the air on April 26, 1943.