Television great Mary Tyler Moore, the beloved star of "The Dick Van Dyke Show" and "The Mary Tyler Moore Show," died Wednesday in Connecticut, her publicist confirmed. She was 80.

"Today, beloved icon, Mary Tyler Moore, passed away at the age of 80 in the company of friends and her loving husband of over 33 years, Dr. S. Robert Levine," read the statement from Mara Buxbaum, her longtime rep. "A groundbreaking actress, producer, and passionate advocate for the Juvenile Diabetes Research Foundation, Mary will be remembered as a fearless visionary who turned the world on with her smile."

The vivacious brunette performer transformed the image of women on television first as Van Dyke's sexy, vulnerable wife Laura Petrie and then as single career girl Mary Richards in her own series. Her work in the two series brought Moore five Emmy Awards, in 1965, 1966, 1973, 1974 and 1976. She won another Emmy for 1993 TV special "Stolen Babies."

Moore was also a powerhouse producer via her MTM production company with then-husband Grant Tinker, producing her own series as well as "The Bob Newhart Show" and spinoff series "Rhoda" and "Lou Grant," among others.

She combined wholesomeness and sex appeal with cracker-jack comedic timing. In many ways Moore was a throwback to Hollywood golden era leading ladies like Myrna Loy and Jean Arthur, but with a decidedly updated twist.

Her role as Laura Petrie, the suburban wife of comedy writer Rob Petrie, also represented a step forward for the portrayal of women on television. Though they maintained separate beds, the Petries otherwise shared an active, romantic marital life. And unlike Desi Arnaz on "I Love Lucy," Van Dyke's character was not threatened by his wife's talents or her intelligence.

The series made Moore a star, and she worked on films under contract at Universal. With the exception of "Thoroughly Modern Millie," in which she played third fiddle to Julie Andrews and the scene-stealing Carol Channing, the studio's attempts to fashion her in the Doris Day mold was unsuccessful. Moore also tried her hand at the Broadway stage, co-starring with Richard Chamberlain in David Merrick's musical version of Truman Capote's "Breakfast at Tiffany's."

With the help of her second husband, producer Tinker, and the talents of creators James L. Brooks and Allan Burns, she fashioned a new series, "Mary Tyler Moore," which debuted on CBS in 1970 and revolutionized the sitcom. Even more than the Van Dyke show, it focused heavily on the central character's work life.

And in this case the central character was a single woman, Mary Richards, carving out a life for herself in Minneapolis. Moore was the pragmatic and delightfully vulnerable center of a strong ensemble cast that included Ed Asner, Valerie Harper, Betty White, and Ted Knight. "Mary Tyler Moore" raked in the accolades during its run and thereafter was a permanent fixture in television syndication.

"The Mary Tyler Moore Show" won the Emmy for comedy show three years in a row, was named as one of the most influential TV shows of all time on numerous lists, and was one of the first shows to tackle issues including equal pay for women, divorce, infidelity, homosexuality, premarital sex, and infertility. Moore's character even recovers from an addiction to sleeping pills during the show.

Leslie Moonves, chairman and CEO of CBS Corporation, said in a statement on Wednesday: "Mary Tyler Moore was a once-in-a-generation talent. She will be long remembered as a gifted actress, television pioneer and a role model to so many. CBS has lost one of the very best to ever grace our airwaves and our industry has lost a true legend and friend."

After "Mary Tyler Moore," which Moore retired after seven seasons, she tried other series including sitcom "Mary," variety hour "The Mary Tyler Moore Hour" and "New York News," another attempt to recapture the magic of her landmark '70s TV series. There was even an effort to reunite her with Harper, her Rhoda sidekick on "Mary Tyler Moore," starting with a TV movie, "Mary and Rhoda."

The actress finally snared a role that challenged her abilities in Robert Redford's Oscar-winning directorial debut, 1980's "Ordinary People." She played completely against type as a stern, cold matriarch, living in denial after the death of her favorite son. The beautifully wrought performance brought her an Oscar nomination. Then in the mid '90s she was again offered a film role, supporting this time, that displayed her range: As a neurotic, overbearing Jewish mother in "Flirting With Disaster," Moore was hilarious in a completely different way than in any of her TV comedy appearances.

Moore also returned to Broadway stage, finding some success in the drama "Whose Life Is It Anyway?" and taking home a special Tony for her performance. She also appeared on the Rialto in A.R. Gurney's "Sweet Sue" in 1987.

On TV, she carved a niche for herself in TV movies, most notably the breast cancer tale "First You Cry" and the miniseries "Lincoln," in which she played Mary Todd Lincoln. She drew Emmy nominations for both. There was also "Finnegan Begin Again," "Heartsounds" and "Just Between Friends," which brought her good reviews and award recognition.

Moore continued in TV movies during the 2000s, including the sentimental "Miss Lettie and Me," and she guested on series including "That '70s Show," "Lipstick Jungle" and, in 2011, "Hot in Cleveland," where she reunited with her "Mary Tyler Moore Show" co-star Betty White. There was also a reunion show, 2004's "The Dick Van Dyke Show Revisited," in which she participated.

In 1983, after almost 20 years of marriage, Moore separated from Tinker, who had gone on to run NBC and sold to her his share in MTM Enterprises, which she subsequently sold. The company had been very successful with several spinoffs from the "Mary Tyler Moore Show" as well as other hit series like "Hill Street Blues" and "WKRP in Cincinnati."

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