According to Fields' 2003 biography, the vehicle crashing into the drugstore was a real accident that occurred during filming. The director decided to leave it in to give the film the appearance of having a bigger budget.
In the soda-shop scene, Fields turns to the camera and announces that the scene was supposed to have been filmed in a saloon "but the censor cut it out". He was telling the truth.
Several cast members in studio records/casting call lists for this movie were not seen in the final print. These were (with their character names): Richard Alexander (Burly Man), William Alston (Circus Attendant), Al Hill (Studio Policeman), James C. Morton (Studio Policeman), Lloyd Ingraham (Doctor) and Armand 'Curly' Wright (Doctor).
The frantic race down the Hyperion Street bridge on Glendale Avenue when Field's car is hooked onto the firetruck: Look to the upper far right of the scene in the distance and you will see the Great Mausoleum of Forest Lawn where Fields would eventually be interred in the Columbarium of Nativity.
The last movie he starred in, Never Give a Sucker an Even Break, included a character Fields always wanted to have in one of his movies: a young woman (in this case his niece, played by Gloria Jean) who loved him unconditionally.
The title came from dialog in the final scene of W.C. Fields' big stage hit (and later film) "Poppy".
This was the last movie to feature Fields as the main character; his remaining film work had him in supporting roles or cameos, as his health began to decline.