"The Screen Guild Theater" broadcast a 30 minute radio adaptation of the movie on May 13, 1946 with Ronald Colman reprising his film role.

Jean Arthur was 41 when she made this film.

Lloyd Bridges' tiny role was one of 20 film appearances he made in 1942 alone.

A radio theatre presentation of The Talk of the Town was broadcast on CBS radio on the Lux Radio Theatre on 5/17/1943; with Cary Grant, Ronald Colman and Jean Arthur recreating their roles from the movie. It's a 60 minute adaptation of the movie.

According to Columbia publicity materials, Claire Trevor was to play a second female lead. Although she was also in a production cast list, she did not appear in the movie.

Sound chief John P. Livadary was dissatisfied with the sound recorded for the rain scene, so he substituted it with the track used for the rain scene in Only Angels Have Wings.

The studio considered filming two different endings, with Jean Arthur pairing off with Cary Grant in one, and with Ronald Colman in the other, and letting the audience decide by voting in sneak previews which one they preferred. However, in the papers of director George Stevens, all the screenplay drafts contained the current ending. In one draft, an additional unrelated scene was added, but dropped during production.

This was the first time since the silent era that Ronald Colman was billed below another male lead.