Bela Lugosi was slated for the role of Dracula, but the film was dependent upon the presence of Boris Karloff being released from the stage tour of Arsenic and Old Lace. Shooting was delayed, and John Carradine was cast instead of Lugosi, who had a prior engagement: ironically, playing Karloff's "Jonathan Brewster" role in another touring company of "Arsenic and Old Lace."
Glenn Strange was the fourth actor to play the Monster in Universal's Frankenstein series. The actor who played the original Monster, Boris Karloff, was also present in the film, playing the role of Dr. Niemann. Being on the set, Karloff was able to personally coach Strange in the way the Monster should be played.
Of the 5 'Wolf Man' films featuring Lon Chaney Jr; this is the only entry that does NOT feature the Wolf Man's growl or howl. It may be there but, if it is, it's drowned out by Hans J Salter's music score.
Originally Kharis the mummy, another Universal "classic monster", was to be in the movie but was removed because of budget restrictions.
Originally titled 'The Devil's Brood', this was given a $354,000 budget and a relatively generous (by Universal standards) 30-day shooting schedule. Star Boris Karloff earned $20,000 and Lon Chaney Jr. received a flat $10,000 for his third appearance as the Wolf Man. John Carradine and J. Carrol Naish were both paid $7,000 each. Lionel Atwill earned $1750 and George Zucco was paid $1500. Glenn Strange was paid $500 for his role as Frankenstein's monster.
Part of the SON OF SHOCK package of 21 titles released to television in 1958, which followed the original SHOCK THEATER release of 52 features one year earlier.
Shooting lasted from April 4-May 8, 1944, released December 15.
The spelling of the town of Vasaria from the previous film in the series,"Frankenstein Meets the Wolfman," is changed to Visaria.
The title "House of..." could refer to the ruins/house owned by Ludwig Frankenstein, the second son of Henry Frankenstein (portrayed by Cedric Hardwicke) in The Ghost of Frankenstein. It's also the same "house" where Lawrence Talbot discovers the Monster in ice in Frankenstein Meets the Wolf Man; and, of course, where Neiman discovers the Wolfman and the Monster in this film. (The castle is entirely washed away in the flood at the climax of " - Meets the Wolf Man," but is inexplicably semi-intact here.
This is the first of the Universal Frankenstein films in which a member of the Frankenstein family does not appear, unless you count the monster himself as part of the family. According to Bride of Frankenstein, his name is Frankenstein as well.
Universal employed an actress to dub actress's screams for their horror films, but Elena Verdugo's scream worked so well, it was retained in the final version.
When Daniel (J. Carrol Naish) is thrown off the roof his scream is that of Boris Karloff as the Frankenstein Monster when he finds Ygor's body in Son of Frankenstein.