Myrna Loy (uncredited) can be recognized as the chained prisoner directly behind Manon in the prison, on the wagon, and on the deck of the ship.

John Barrymore and Dolores Costello married the following year.

A print of this film and soundtrack for it survive in the UCLA Film and Television Archives.

After "The End" appears on the screen, the entire Vitaphone Symphony Orchestra and its conductor (Herman S. Heller) appears on the screen, partly in closeup, for about 15 seconds. The New York Times reviewer of 4 February 1927 noted that the Vitaphone synchronization process was so good that he, and probably most of the audience, had forgotten that there was no orchestra in the pit. When the orchestra and conductor were shown onscreen, the surprised audience loudly cheered.

The 2009 Warner Archive DVD boxcover is incorrect. The photo on the box front is from another movie, the United Artist film The Beloved Rogue. Both films were, however, directed by 'Alan Crosland' and starred John Barrymore.

The working title of "Manon Lescaut" was changed, because an Ufa film with that title opened in New York 29 November 1926.

This film was restored jointly by the UCLA Film and Television Archive (which had a copy of the print and soundtrack) and the George Eastman House International Museum of Photography and Film (which provided some picture elements). It was shown on the Turner Classic Movies (TCM) channel in 2006 and has a running time of 111 minutes plus another minute for restoration credits.