At a time when most African-Americans were stereotyped, both Nina Mae McKinney and Clarence Muse were the two most reputable characters in the movie. Although their parts in the script are written in dialect, both spoke normally.

In New York, newspaper advertising featured a warning that "Safe in Hell" was "NOT Recommended for Children".

In September 1928, Warner Bros. Pictures purchased a majority interestin First National Pictures and from that point on, all "First National" productions were actually made under Warner Bros. control, even though the two companies continued to retain separate identities until the mid-1930's, after which time "A Warner Bros.-First National Picture" was often used.

Vitaphone production reels #5056-5063.