"Lux Radio Theater" broadcast a 60 minute radio adaptation of the movie on November 15, 1937 with Edward Arnold and Mary Nash reprising their film roles.

"The Screen Guild Theater" broadcast a 30 minute radio adaptation of the movie on March 15, 1942 with Walter Brennan and Edward Arnold reprising their film roles.

Howard Hawks stated that William Wyler's contribution was only ten minutes of screen time. However, it's generally thought that Wyler directed the last 30 minutes of the film.

Howard Hawks's take on his being "fired" is that he wasn't. Rather, he quit, after refusing to agree with Samuel Goldwyn, who wanted the narrative to stay closer to that of the book. Goldwyn had been ill and absent for the 42 days of shooting that Hawks directed and was unaware of Hawks' rewrites. Hawks left the production with only 14 days left to go.

Director Howard Hawks was replaced by William Wyler after Hawks was rude to producer Samuel Goldwyn.

The Song, "Aura Lea," was popularized with new lyrics "Love Me Tender" by Elvis Presley, Ken Darby and Vera Matson in 1956. When Come and Get It was released, another song. "Aura Lee," by Hugo Frey, was published with a picture of Frances Farmer on its cover. However, the song she sings in the movie has music and lyrics from the older song.

The world premiere was at the Liberty Theatre in Seattle, Washington, where Frances Farmer once worked as an usherette.

Walter Brennan won the very first Supporting Actor Oscar for his role as Swan Bostrom. In the span of four years (1936-40), Brennan won a then-unprecedented three acting Oscars, also for "Kentucky" (1938) and "The Westerner" (1940), a feat unmatched until Katharine Hepburn won her third Best Actress award for 1968's "The Lion in Winter". Brennan's Oscar success was seen as largely due in part to the fact that the Screen Extras Guild consistently voted for him, as Brennan had been an extra for many years until his breakout success as one of Hollywood's most respected character actors.